DUPIXENT is an injectable medicine that is administered by subcutaneous injection and is intended for use under the guidance of a healthcare provider.1
  • Patients 12 years of age and older may self-inject DUPIXENT—or a caregiver may administer DUPIXENT—after training has been provided by a healthcare
    provider on proper subcutaneous injection technique using the pre-filled syringe or pen
    • In pediatric patients 12 years of age and older, it is recommended that DUPIXENT be administered under the supervision of an adult
  • It is important to provide proper training to patients and/or caregivers on the preparation and administration of DUPIXENT prior to use
  • After administration, advise patients to follow sharps disposal recommendations
  • Patients and/or caregivers should read the appropriate Instructions for Use

Dosing for Adults/Pediatric Patients (12+ Years) With Moderate-to-Severe Asthma1

For patients with moderate-to-severe asthma with an eosinophilic phenotype

12+ years

Loading dose
600 mg
2 x 300 mgapre-filled pens or syringes
Every 2 weeks
300 mg
1 pre-filled
pen or syringe
OR
 
400 mg
2 x 200 mgbpre-filled pens or syringes
Every 2 weeks
200 mg
1 pre-filled
pen or syringe
OCS-dependent asthma patients or patients with comorbid moderate-to-severe atopic dermatitis or adults with comorbid chronic rhinosinusitis with nasal polyposis1

12+ years

Loading dose
600 mg
2 x 300 mgapre-filled pens or syringes
Every 2 weeks
300 mg
1 pre-filled
pen or syringe
OR

a 300 mg=2 mL solution.
b 200 mg=1.14 mL solution.

Dosing for Pediatric Patients (6-11 Years) With Moderate-to-Severe Asthma1

30 kg
or
morec

200 mg
1 pre-filled syringe
Every 2 weeks

15 kg to <30 kgd

Every 2 weeks
100 mge
1 pre-filled syringe
Or
Every 4 weeks
300 mg
1 pre-filled syringe

No loading dose.
For pediatric patients (6‑11 years) with asthma and comorbid moderate-to-severe atopic dermatitis, follow the recommended dosage for atopic dermatitis, which includes an initial loading dose.

c30 kg is equal to 66 lb.
d15 kg is equal to 33 lb.
e100 mg=0.67 mL solution.

At-home or In-office Administration Options

Important Administration Instructions1

  • For the initial dose, administer each of the 2 injections at different injection sites
  • Administer the subcutaneous injection into the thigh or abdomen, except for the 2 inches (5 cm) around the navel
  • The upper arm can also be used if a caregiver administers the injection
  • Rotate the injection site with each injection. DO NOT inject DUPIXENT into skin that is tender, damaged, bruised, or scarred

See the Instructions for Use for more detailed instructions on the preparation and administration of DUPIXENT.

Pre-filled Pen
Instructions for Use - 200 mg Instructions for Use - 300 mg
Pre-filled Syringe
Instructions for Use - 100 mg Instructions for Use - 200 mg Instructions for Use - 300 mg
Supplemental Injection Training

 

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Preparation for Use1

Before injection, instruct patients and/or caregivers to remove DUPIXENT from the refrigerator and allow DUPIXENT to reach room temperature without removing the needle cap.

  • 45 minutes for the 300 mg/2 mL pre‑filled syringe or pre-filled pen
  • 30 minutes for the 200 mg/1.14 mL pre‑filled syringe or pre-filled pen
  • 30 minutes for the 100 mg/0.67 mL pre-filled syringe

Patients and/or caregivers should inspect DUPIXENT for particulate matter and discoloration prior to administration.

  • Do not use if the liquid contains visible particulate matter or is discolored or cloudy (other than clear to slightly opalescent, colorless to pale yellow)

Patients and/or caregivers should discard any unused product remaining in the pre‑filled syringe or pre-filled pen in accordance with local requirements.

Storage and Handling1

  • DUPIXENT is sterile and preservative‑free. Patients and/or caregivers should discard any unused portion
  • Patients and/or caregivers should store DUPIXENT by refrigerating at 36 °F to 46 °F (2 °C to 8 °C) in the original carton to protect
    from light
  • If necessary, DUPIXENT may be kept at room temperature up to 77 °F (25 °C) for a maximum of 14 days. DUPIXENT should not be stored above 77 °F (25 °C). After removal from the refrigerator, DUPIXENT must be used within 14 days or discarded
  • DUPIXENT should not be exposed to heat or direct sunlight
  • Any unused medicinal product or waste material should be disposed of in accordance with local requirements
  • Do NOT freeze. Do NOT shake
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