DUPIXENT Significantly Reduced the Frequency and Severity of Dysphagia1,2

Significant improvements in DSQ score demonstrated at Week 241,a,b

  • aPart A (coprimary endpoint).
  • bTotal biweekly DSQ scores range from 0 to 84; higher scores indicate greater frequency and severity of dysphagia.
  • cWeek 4 assessment is a post-hoc analysis; results are descriptive.

Part B (Week 24; coprimary endpoint)1

  • Absolute change from baseline at Week 24: -23.8 (SE 1.9) with DUPIXENT (n=80) vs -13.9 (SE 1.9) with placebo (n=79) (LSM difference: -9.9 [95% CI: -14.8, -5.0])

The Dysphagia Symptom Questionnaire (DSQ)

A patient-reported assessment of the frequency and severity of dysphagia;
reduced score indicates improvement.4

DUPIXENT provided greater histologic improvements1-3

Histological remission at Week 24
(peak esophageal intraepithelial EOS count ≤6 EOS/HPF)d

Histological response at Week 24
(peak esophageal intraepithelial EOS count <15 EOS/HPF)e

  • dParts A and B (coprimary endpoint).
  • eParts A and B (secondary endpoint). In Part B, this endpoint was ordered after the point at which hierarchical testing procedure failed; results are descriptive.

Peak Esophageal Intraepithelial Eosinophil Count

Used to confirm diagnosis and determine treatment response. Histologic data are reported as the percentage of patients achieving the defined EOS threshold.5

Endoscopic Reference Score (EREFS) Reduced at Week 242,3,f

EREFS total score

  • fParts A and B (secondary endpoint). Results are descriptive; thresholds for clinically meaningful changes in EREFS scores have not been established. Additionally, in Part B this endpoint was ordered after the point at which hierarchical testing procedure failed.

Endoscopic Reference Score (EREFS)

EREFS is a clinician-reported rating of the severity of 5 endoscopic features: edema, rings, exudates, furrows, and strictures.6

  • EOS/HPF, eosinophils per high-power field; LSM, least squares mean
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