Measured by SNOT-22, a QoL questionnaire used for CRSwNP patients1

Turn to DUPIXENT to improve a range of CRSwNP symptoms
and QoL measures2

aWeek 4 in SINUS-52. LSM difference between DUPIXENT 300 mg Q2W + INCS (n=150) and placebo + INCS (n=153): -10.57 (95% CI: -14.47, -6.66) (-18.97 from a baseline score of 50.16 vs -8.40 from a baseline score of 53.48, respectively).1

bWeek 24 in SINUS-52. LSM difference between DUPIXENT 300 mg Q2W + INCS (n=150) and placebo + INCS (n=153): -16.76 (95% CI: -20.85, -12.67) (-27.08 from a baseline score of 50.16 vs -10.32 from a baseline score of 53.48, respectively).1

cWeek 52 in SINUS-52. LSM difference between DUPIXENT 300 mg Q2W + INCS (n=150) and placebo + INCS (n=153): -20.96 (95% CI: -25.03, -16.89) (-29.84 from a baseline score of 50.16 vs -8.88 from a baseline score of 53.48, respectively).1

dWeek 24 (key secondary endpoint). LSM difference between DUPIXENT 300 mg Q2W + INCS (n=295, pooled arms) and placebo + INCS (n=153): -17.36 (95% CI: -20.87, -13.85) (-27.77 from a baseline score of 51.02 vs -10.40 from a baseline score of 53.48, respectively) (P<0.0001).1

SNOT-22 measures
the QoL of CRSwNP
patients3

The SNOT-22 score is calculated from a patient questionnaire where 22 symptoms are rated from 0 (“no problem”) to 5 (“as
bad is it can be”) based on the severity and frequency of each particular item.2,3

The study was not designed to measure the impact of treatment on the individual components. Therefore, improvement in
the total aggregate SNOT-22 score does not necessarily correlate with a positive effect on each individual item or domain.

Sleep

  • Difficulty falling asleep
  • Wake up at night
  • Lack of a good night's sleep

Function

  • Wake up tired
  • Fatigue
  • Reduced productivity
  • Reduced concentration

Ear/Facial

  • Ear fullness
  • Dizziness
  • Ear pain
  • Facial pain/pressure

Emotional

  • Frustrated/restless/irritable
  • Sad
  • Embarrassed

Nasal

  • Need to blow nose
  • Nasal blockage
  • Sneezing
  • Runny nose
  • Cough
  • Post-nasal discharge
  • Thick nasal discharge
  • Decreased sense of smell/taste

22-item Sino-Nasal Outcome Test (SNOT-22) score (range 0-110); reduced score indicates improvement.2

INCS, intranasal corticosteroid; LSM, least squares mean; Q2W, once every 2 weeks; QoL, quality of life.

SEE LMK-CT RESULTS
BACK TO NASAL POLYP SCORE RESULTS

Dosage and
Administration

See the recommended dosing and administration options for patients on DUPIXENT.